GLP-1 Comparison Chart
Written by: Melanie Batchelor, MHS, RD, LDN, CDCES
1 minute read
August 31, 2026
Not all GLP-1s work the same way. See how they compare – how they’re taken, what they treat and what results to expect.
GLP-1 Comparison Chart
| Brand Name | Who makes the medication? | Active Ingredient | How do you take it? | Approved Uses | Average A1C Reduction | *Approx. Weight Loss | Studied in Type 1 Diabetes? |
| Foundayo | Lilly | Orforglipron | Daily oral tablet taken anytime | Weight Loss | No Data | 25 lbs | No |
| Mounjaro** | Lilly | Tirzepatide | Once weekly injection | T2D, CVD | 1.8% - 2.4% | 18 lbs | Yes |
| Ozempic | Novo Nordisk | Semaglutide | Once weekly injection | T2D, CVD, CKD | 1.4% - 2.1% | 14 lbs | Yes |
| Rybelsus or Ozempic Pill | Novo Nordisk | Semaglutide | Daily oral tablet (upon waking with no more than 4 oz water on an empty stomach) | T2D, CVD | 1.0% - 1.3% | 6 lbs | No |
| Saxenda | Novo Nordisk | Liraglutide | Daily injection | Weight Loss | No Data | 21 lbs | No |
| Trulicity | Lilly | Dulaglutide | Once weekly injection | T2D, CVD | 0.7% - 1.8% | 10 lbs | Yes |
| Victoza | Novo Nordisk | Liraglutide | Daily injection | T2D, CVD | 1.0% - 1.5% | 6 lbs | Yes |
| Wegovy Injection | Novo Nordisk | Semaglutide | Once weekly injection | Weight Loss, CVD, MASH | No Data | 35 lbs | Yes |
| Wegovy Pill | Novo Nordisk | Semaglutide | Daily oral tablet (upon waking with no more than 4 oz water on an empty stomach) | Weight Loss | No Data | 33 lbs | No |
| Zepbound** | Lilly | Tirzepatide | Once weekly injection | Weight Loss, OSA | No Data | 50 lbs | Yes |
*Weight loss is dependent upon starting weight, medication dose, and other factors- results will vary
** Combo GLP-1 & GIP
CVD= Cardiovascular Disease, T2D= Type 2 Diabetes, CKD= Chronic Kidney Disease, MASH= Metabolic Dysfunction-Associated Steatohepatitis, OSA= Obstructive Sleep Apnea
Expert tip: Not all GLP-1s are created equal. You’ve probably seen TV commercials for cheaper, compounded versions of GLP-1 medications that are available through third-party sellers. But they aren’t FDA-approved and come with real safety risks. Stick with FDA-approved options and patient assistance programs widely available. They’re worth the extra step.
Author
Melanie Batchelor, MHS, RD, LDN, CDCES
Beyond Type 1 is the largest diabetes org online, funding advocacy, education and cure research. Find industry news, inspirational stories and practical help. Join the 1M+ strong community and discover what it means to #LiveBeyond a diabetes diagnosis.
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